Alcohol use disorder (AUD) remains a significant global health issue. Medications like Acamprosate have become essential in treating alcohol dependency. The 2022 National Survey on Drug Use and Health (NSDUH) reported that nearly 29 million adults aged 18 and older experienced AUD in the past year.
Acamprosate, also known as Acamprosate calcium, helps individuals with alcohol dependence maintain abstinence. Clinical trials have shown that it can reduce the risk of relapse by 86% for those struggling with alcoholism.
While the exact mechanism of Acamprosate is still under study, scientists believe it works by restoring the balance of brain chemicals disrupted by alcohol dependence. It helps regulate these imbalances, supporting recovery.
Unlike medications that primarily address alcohol withdrawal, Acamprosate focuses on reducing cravings and preventing relapse. This makes it a valuable tool in achieving long-term recovery from alcohol addiction.
Alcohol dependence can increase glutamate levels, heightening brain activity. Acamprosate may reduce this excessive activity, promoting a calmer state.
Inhibitory neurotransmitters help calm brain activity. Acamprosate may enhance their levels or sensitivity, counteracting glutamate’s hyperactivity.
Acamprosate may interact with NMDA receptors, which are involved in learning and memory. This could weaken the link between alcohol cues and their rewarding effects, reducing cravings.
Some studies suggest Acamprosate might affect calcium channels in neurons, contributing to its ability to stabilize brain activity.
Although Acamprosate is generally well-tolerated, it can cause side effects that some people may find unpleasant. Being aware of these potential effects allows patients to make informed treatment decisions. Healthcare providers typically discuss these side effects before prescribing the medication.
Acamprosate can be beneficial for individuals at different stages of alcohol dependence. Here’s what to expect during the treatment process:
Doctors evaluate your medical history and assess the severity of your alcohol dependence. They may also check for kidney issues and rule out other pre-existing conditions.
Healthcare professionals will provide detailed information about the drug including potential benefits, side effects, and alternative treatment options.
Acamprosate is usually taken orally three times a day, with or without food. The standard dose is 666 mg per tablet, meaning you’ll typically take two tablets per dose.
Regular doctor visits are essential to monitor your progress. Your doctor may adjust your dosage if needed and manage any side effects that arise.
For best results, Acamprosate is combined with counseling, support groups, and lifestyle adjustments. These therapies address the emotional and social factors contributing to alcohol dependence.
Long-term use is often recommended, with treatment typically lasting several months. Staying involved in therapy, support groups, and maintaining a healthy lifestyle are key to preventing relapse.
Acamprosate has a half-life of approximately 30 to 33 hours when taken orally. Its elimination rate can differ depending on factors such as dosage, kidney function, and whether it’s taken with food.
Acamprosate is not fully soluble with water. The drug has a bioavailability of only about 11%, meaning the bloodstream only absorbs this amount.
Once absorbed, Acamprosate does not extensively bind to plasma proteins. This means that it is fairly freely available to distribute throughout the body. It does not cross the blood-brain barrier to any significant extent.
Instead of the liver, the kidneys metabolize Acamprosate. The body eliminates about half of the drug through urine within 24 hours.
Acamprosate has no known severe drug interactions, but it can moderately interact with Naltrexone, another medication used for alcohol dependence treatment.
Naltrexone is commonly used in Medication-Assisted Treatment (MAT) for both opioid and alcohol dependence by blocking opioid receptors in the brain.
When combined, these medications may increase the risk of side effects such as headaches or dizziness. However, doctors may sometimes recommend using both since they address different aspects of addiction.
Unlike medications like Disulfiram (Antabuse), drinking alcohol while taking Acamprosate typically won’t lead to immediate or severe reactions. Since Acamprosate doesn’t directly interact with alcohol, it usually doesn’t cause unpleasant side effects. However, consuming alcohol can reduce the drug’s effectiveness and interfere with its purpose of supporting abstinence.
Acamprosate is not a cure for alcoholism, but it can help manage the condition and reduce the risk of relapse when used alongside other treatments. Consulting with healthcare professionals is essential to create a personalized treatment plan that suits your needs.
At Mesa Detox, we focus on your well-being by addressing both the physical and mental aspects of addiction. Our comprehensive program offers medical detox, counseling, therapy, and additional support to guide you through recovery.
If you or a loved one is facing alcohol addiction, we’re here to help. Contact our team today to explore our treatment options.
